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NOTE!  The report described below has been updated by Report #S180, published October 2010

See details at "Worldwide Surgical Sealants,
Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015"


Worldwide Surgical Sealants, Glues and Wound Closure Market

January 2005

Report #S122

214 pages   58 Exhibits   56 Company Profiles   Report #S122

This report details the complete range of sealants & glues technologies, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesive. The report examines the clinical and technology developments underlying this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity. 

Table of Contents



An Important Healthcare Segment


Demographic trends

Patient Driven Product Selection

Mechanisms of Repair

Commercial Imperatives

Industry Consolidation

Clinical Caseload

Market Segmentation and Dynamics

New Applications for Adjunctive Closure and Securement Products

Benefits of Adjunctive Surgical Closure and Securement Products

History of Use

Evolution of Commercial Markets for Sealants and Adhesives

Company Strategies ó Overview


1.1       Anatomy and Physiology of Tissue Repair

1.1.1          Skin Surface Tissues and Organs

1.1.2          Internal Tissues and Organs

1.2       Wound Classification and Types

1.2.1          Classification Wound Characteristics Wound Etiology

1.2.2          Surgical Wounds       Cardiovascular          Introduction          Coronary Heart Disease          Myocardial Infarction          Congestive Heart Failure          Dysfunctional Heart Valves          Peripheral Vascular Disorders          Abnormal Aortic Aneurysms          Drivers of Caseloads for Cardiac Surgery       Neurological          Introduction          Stroke          Parkinsonís Disease          Epilepsy          Traumatic Injury          Peripheral Nerve Treatment          Neurology Drivers       Orthopedic          Introduction          Cartilage Repair          Ligament Damage          Bone Graft Materials          Vertebral Disc Repair          Drivers of Orthopedic Surgery       Urological          Introduction          Incontinence          Drivers of Urological Surgery       Skin          Introduction          Burns          Pressure Ulcers          Diabetic Ulcers          Venous Ulcers          Plastic Surgery       Fibrin Glue and Sealants as a Vital Tools in the Surgeonís Armamentarium       Uses of High Strength Glues in Surgical Applications


2.1       Tissue Healing

2.1.1          Hemostasis

2.1.2          Proliferative Phase

2.1.3          Factors That Affect Healing

2.2       Development, Clinical, Regulatory and Cost-Effectiveness Challenges

2.2.1          Development

2.2.2          Delivery Systems

2.2.3          Cost Effectiveness

2.2.4          Clinical

2.2.5          Regulatory


3.1       Overview

3.2       Sutures and Staples

3.2.1          Competitors and Products       Overview       Companies

3.2.2          Products in Development

3.2.3          Market Analysis and Forecast

3.3       Tapes

3.3.1          Competitors and Products

3.3.2          Products in Development

3.3.3          Market Analysis and Forecast

3.4       Hemostats

3.4.1          Competitors and Products

3.4.2          Products in Development

3.4.3          Market Analysis and Forecasts

3.5       Fibrin and Sealant Products

3.5.1          Overview

3.5.2          Competitors and Products

3.5.3          Products in Development

3.5.4          Fibrin and Sealant Market and Competitive Activity

3.6       High-Strength Medical Adhesives

3.6.1          Competitors and Products

3.6.2          Products in Development

3.6.3          Market Analysis and Forecasts

3.7       Post-Surgical Adhesion Prevention

3.7.1          Competitors and Products

3.7.2          Products in Development

3.7.3          Market Analysis and Forecasts

Section 4:        COMPANY PROFILES

4.1       Angiotech Pharmaceuticals Inc

4.2       Advanced Medical Solutions plc

4.3       Anika Therapeutics Inc.

4.4       ARC Pharmaceuticals

4.5       Aventis Behring

4.6       Bard Medical Division / C.R. Bard, Inc.

4.7       Baxter International Inc.

4.8       ZLB Behring

4.9       Biocoral Inc.

4.10     Biovascular Inc. ((Synovis Life Technologies)

4.11     B. Braun Melsungen AG

4.12     Chemence Limited

4.13     Closure Medical Corporation

4.14     Cohesion Technologies Inc.

4.15     Collagen Matrix Inc.

4.16     Confluent Surgical Inc.

4.17     CryoLife, Inc.

4.18     (CSMG) Consortium Service Management Group

4.19     CuraMedical BV

4.20     Johnson & Johnson (Ethicon)

4.21     Fehling Medical AG/Berlin Heart

4.22     FibroGen, Inc.

4.23     Fidia Advanced Biopolymers

4.24     Focal Inc./Genzyme BioSurgery

4.25     Fusion Medical Technologies Inc./Baxter

4.26     FzioMed Inc.

4.27     GEM SRI

4.28     Genzyme Biosurgery Inc.

4.29     Glustitch Inc.

4.30     Haemacure Corporation

4.31     Harvest Technologies Corporation

4.32     HemCon, Inc.

4.33     Integra Life Sciences Holdings Corp.

4.34     Interpore Cross International/Biomet

4.35     Kensey Nash Corporation

4.36     King Pharmaceuticals

4.37     Lifecore Biomedical, Inc.

4.38     Marine Polymer Technologies

4.39     Medafor, Inc.

4.40     MedLogic Global Corporation/Advanced Medical Solutions plc

4.41     Nycomed Pharma

4.42     Onux Medical Inc.

4.43     Organogenesis Inc.

4.44     Pharming Group NV

4.45     Plasmaseal

4.46     Polyganics

4.47     Smith & Nephew plc

4.48     Spiration Inc.

4.49     Synovis Life Technologies

4.50     Thermogenesis Corporation

4.51     Tissuemed Ltd

4.52     Tyco International Inc.

4.53     US Biomedical, Inc. (Life Medical Sciences Inc.)

4.54     US Surgical Corp.

4.55     Vivolution

List of Exhibits

Exhibit ES-1:  Recent Acquisitions within the Securement Segment

Exhibit ES-2:  Introduction of New Securement Technologies to the U.S. Market

Exhibit ES-3:  Definition of Surgical Closure and Securement Products

Exhibit ES-4:  Availability of Sealant Products from Selected Companies

Exhibit ES-5:  Availability of High Strength Glue Products from Example Companies

Exhibit ES-6:  Incidence of Two Example Surgical Procedures with High Requirement for Adjunctive Products for Surgical Closure and Securement

Exhibit ES-7:  U.S. FDA Approved Uses of Sealants, Glues, and Hemostats

Exhibit ES-8:  Synthetic and Biological Sealant Competitors (Non-Fibrin Sealants)

Exhibit ES-9:  Selected High Strength Adhesive Companies and Their Strategies

Exhibit ES-10:  Selected Sealant Product Companies and Their Strategies

Exhibit ES-11:  Worldwide Growth in the Securement and Closure Market, 2004-2014

Exhibit 1-1:  Skin Structure Illustrating Major Organelles and Skin Layers

Exhibit 1-2:  Classification of Wounds by Morphology

Exhibit 1-3:  Severity Classification of Wounds

Exhibit 1-4:  Current Uses of Adjunctive Surgical Closure Products

Exhibit 1-5:  2004, Worldwide Wound Incidence by Etiology

Exhibit 1-6:  Criteria for Adjunctive Use of Hemostats, Sealants, High Strength Adhesives and Adhesion Prevention Products for Surgery

Exhibit 1-7:  Surgical Procedures with Potential Requirements for Hemostats, Sealants, High Strength Adhesives and Adhesion Prevention Products

Exhibit 1-8:  Potential for Cardiovascular Applications, Incidences of Applicable Surgical Disorders (000s), 2004

Exhibit 1-9:  Potential for Neurological Applications, Incidences of Applicable Disorders (000s), 2004

Exhibit 1-10:  Potential for Orthopedic Applications, Numbers of Major Surgical Interventions (000s), 2004

Exhibit 1-11:  Potential for Urological Applications, Incidence of Applicable Disorders (000s), 2004

Exhibit 1-12:  Potential for Dermal Repair, Incidence of Applicable Disorders (000s), 2004

Exhibit 1-13:  Applications of Fibrin and Other Sealants

Exhibit 1-14:  Surgical Procedures Using Fibrin and Other Sealant Products (1990-2002)

Exhibit 1-15:  Surgical Indications for High Strength Glues (Europe - 2002)

Exhibit 2-1:  Factors That Impact on Wound Healing

Exhibit 2-2:  Timescales for Development of Closure and Sealant Products

Exhibit 2-3:  Variables associated with Clinical Evaluation of Closure and Securement, and Related Products

Exhibit 2-3:  Clinical Development and Approvals (USA)

Exhibit 3-1:  Companies Commercializing Technologies in the Surgical Suture and Staples Category

Exhibit 3-2:  Worldwide Sutures and Staples, Market Forecast, 2004-2014

Exhibit 3-3:  2004, Worldwide Suture and Staples Market, Share by Supplier

Exhibit 3-4:  Companies Commercializing First Aid Technologies That Are Often Used as Tapes for Closure

Exhibit 3-5:  Worldwide Tapes Market Forecast, 2004-2014

Exhibit 3-6:  2004, Worldwide Tapes for Closure Market Share by Supplier

Exhibit 3-7:  Companies Commercializing Technologies in the Hemostat Category

Exhibit 3-8:  Worldwide Hemostats Market Forecast, 2004-2014

Exhibit 3-9:  2004, Worldwide Hemostats Market Share by Supplier

Exhibit 3-10:  Companies Commercializing Technologies in the Sealants Category

Exhibit 3-11:  Worldwide Sealants Market Forecast, 2004-2014

Exhibit 3-12:  2004, Worldwide Sealants Market Share by Supplier

Exhibit 3-13:  Companies Commercializing Cyanoacrylate-based High Strength Medical Adhesives

Exhibit 3-14:  Worldwide High Strength Glues Market Forecast, 2004-2014

Exhibit 3-15:  2004, Worldwide High Strength Glues Market Share by Supplier

Exhibit 3-16 Regulatory Status of Surgical Sealant Products

Exhibit 3-17:  Companies Commercializing Technologies in the Post-Operative Adhesion Category

Exhibit 3-18:  Worldwide Post Operative Adhesion Prevention Market Forecast, 2004-2014

Exhibit 3-19:  Worldwide Post Operative Adhesion Prevention Market Share by Supplier

Exhibit 4.1:  Anika Financial Summary

Exhibit 4-2:  Baxter International Healthcare Ė Top-line financial data, 2003 and 2003

Exhibit 4-3:  B. Braun Financial Data

Exhibit 4-4:  Closure Medical Financial Figures

Exhibit 4-5:  CryoLife Inc, Financial Summary

Exhibit 4-6:  Johnson & Johnson Headline Financial Data, Third Quarter 2004 (billions of dollars)

Exhibit 4-7:  Haemacure Corporation Financial Data, Third Quarter 2004

Exhibit 4-8:  Integra Life Sciences Holdings Corp. Financial Results for 2004 and 2003

Exhibit 4-9:  Pharming Group Results for Nine months of 2004 and 2003

Exhibit 4-10:  Synovis Life Technologies Inc, Financial data for Years Ending October 31st 2004 and 2003


Appendix: List of Companies



Worldwide Surgical Sealants, Glues & Wound Closure, 2004-2014,

January 2005


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MedMarket Diligence Reports are produced through primary and secondary research. Data is gathered from published sources on products and technologies on the market and under development.  Clinicians and industry representatives are interviewed for their knowledge and insights on product development, market development, clinical practice and trends associated with the evolving use of technologies. Secondary data is used to corroborate and support assessments and projections.  Reports are written and researched by industry insiders, whose familiarity with the companies, industry dynamics and other marketplace specifics facilitate the research process and ensure high quality and thorough reports.


 Contact: Patrick Driscoll, (949) 859-3401.

Copyright © 2006 MedMarket Diligence, LLC. All rights reserved.
Revised: 02/16/11

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