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Surgical Sealants, Glues and Wound Closure 2009-2013



See February 2012 Report #S190
Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2010-2017

(The report below has been superceded by Report #S190)


Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013


· 322 pages   · 75 Exhibits   · 136 Company Profiles   · Report #S175   · Published January 2009

This report details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.


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This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide current and annual forecast to 2013 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade.  The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a ten-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

Table of Contents

Executive Summary


Demographic trends

Consumer-Driven Product Selection

Mechanisms of Tissue Repair 

Commercial Imperatives

Industry Consolidation

Clinical Caseload

Market Segmentation and Dynamics

New Surgical Techniques Drive Market Opportunity

The Uses of Adjunctive Surgical Closure and Securement Products

Product Development History

Evolution of Commercial Markets for Sealants and Adhesives

Company Strategies — Overview


1.1         Anatomy and Physiology of Tissue Repair

1.2         The Skin

1.3         Internal Tissues and Organs

1.4         Wound Classification and Types

1.4.1         Classification by Morphology and Severity

1.4.2         Wound Classification by Cause

1.4.3         Surgical Wounds

1.5         Caseload

1.5.1         Cardiovascular         Coronary Heart Disease         Dysfunctional Heart Valves         Peripheral Vascular Disorders         Abnormal Aortic Aneurysms         Drivers of Caseloads for Cardiac Surgery

1.5.2         Neurological         Stroke         Parkinson’s Disease         Epilepsy         Traumatic Injury         Peripheral Nerve Treatment         Neurology Drivers

1.5.3         Orthopedic         Hip Replacements         Knee Replacements         Cartilage Repair         Ligament Damage         Bone Grafting         Vertebral Disc Repair         Drivers of Orthopedic Surgery

1.5.4         Urological         Incontinence         Drivers of Urological Surgery

1.5.5         Skin         Burns         Pressure Ulcers         Diabetic Ulcers         Venous Ulcers         Plastic Surgery

1.6         The Role of Modern Sealant, Securement and Hemostatic Products in Surgery

1.6.1         Fibrin Sealants

1.6.2         High-Strength Glues


2.1         Tissue Healing

2.1.1         Hemostasis

2.1.2         Proliferation and Maturation

2.1.3         Factors That Affect Healing

2.2         Product Development

2.3         Development Timelines

2.3.1         Collagen and Thrombin Combination

2.3.2         Polyethylene Glycol Polymer (PEG)

2.3.3         Albumin Cross-Linked with Glutaraldehyde

2.3.4         Delivery Systems

2.4         Cost Effectiveness

2.5         Regulatory Challenges

2.5.1         Approval Processes

2.5.2         History of Product Development

2.5.3         Regulatory Aspects


3.1         Overview

3.2         Development Timeline

3.3         Sutures, Staples, and Other Mechanical Closure Devices

3.3.1         Competitors and Products

3.3.2         Suppliers

3.3.3         Product Development

3.3.4         Market Analysis and Forecast

3.4         Tapes

3.4.1         Competitors and Products

3.4.2         Products in Development

3.4.3         Market Analysis and Forecast

3.5         Hemostats

3.5.1         Competitors and Products

3.5.2         Products in Development

3.5.3         Market Analysis and Forecasts

3.6         Fibrin and Other Sealant Products

3.6.1         Competitors and Products

3.6.2         Products in Development

3.6.3         Fibrin and Sealant Market and Competitive Activity

3.7         High-Strength Medical Adhesives

3.7.1         Competitors and Products

3.7.2         Products in Development

3.7.3         Market Analysis and Forecasts

3.8         Post-Surgical Adhesion Prevention

3.8.1         Competitors and Products

3.8.2         Products in Development

3.8.3         Market Analysis and Forecasts

3.9         Wound Closure and Securement Markets: Global and Regional Analysis

3.9.1         Americas         United States         Latin America

3.9.2         Japan

3.9.3         Europe

3.9.4         Rest of World

3.10       Worldwide Markets By Country and Segment


Section 4:          Company Profiles


4.1       3DM, Inc. (3D-Matrix, Ltd.)

4.2       3M

4.3       Abbott Vascular

4.4       AccessClosure, Inc.

4.5       Adhezion Biomedical, LLC

4.6       Advanced Medical Solutions plc

4.7       Allerderm

4.8       Angiotech Pharmaceuticals, Inc.

4.9       Anika Therapeutics, Inc.

4.10     ARC Pharmaceuticals

4.11     Arch Therapeutics, Inc.

4.12     ArthroCare Corporation

4.13     Aso LLC

4.14     Aspen Surgical Products

4.15     Atrax Medical Group

4.16     Avery Dennison

4.17     B. Braun Melsungen AG

4.18     Bastos Viegas, s.a.

4.19     Baxter International Inc.

4.20     Bayer HealthCare

4.21     BD (Becton, Dickinson and Company)

4.22     Berlin Heart GmbH

4.23     Bernsco Surgical Supply

4.24     Biocoral Inc.

4.25     BioCore Medical Technologies, Inc.

4.26     Biogentis, Inc.

4.27     Biomet Inc.

4.28     BIOSTER a.s.

4.29     BioSyntech Canada Inc.

4.30     BSN Medical

4.31     C.R. Bard

4.32     Cardiovascular Sciences, Inc.

4.34     Carl Auffarth GmbH & Co. KG

4.35     Cardiva Medical, Inc.

4.36     Ceremed, Inc.

4.37     Chemence Ltd.

4.38     Chemopharma, s.a.

4.39     Cohera Medical, Inc.

4.40     Collagen Matrix, Inc.

4.41     Coloplast A/S

4.42     ConvaTec

4.43     Covidien Ltd.

4.44     CryoLife Inc.

4.45     CSIRO PhotoMedical Technologies

4.46     CSL Behring

4.47     CSMG Technologies, Inc.

4.48     CuraMedical BV

4.49     Cypress Medical Products

4.50     Derma Sciences, Inc.

4.51     Distrex Ibérica S.A.

4.52     DuPont Applied BioSciences

4.53     Entegrion, Inc.

4.54     FibroGen, Inc.

4.55     Fidia Advanced Biopolymers

4.56     Flamel Technologies SA

4.57     Forticell Bioscience

4.58     FzioMed Inc.

4.59     Gelita Medical BV

4.60     GEM srl

4.61     Genzyme Biosurgery Inc.

4.62     GluStitch, Inc.

4.63     Graceduty Company Limited

4.64     GramsMed, LLC

4.65     Haemacure Corporation

4.66     HAPTO Biotech Israel Ltd.

4.67     Hartmann Group

4.68     Harvest Technologies Corporation

4.69     HemCon Medical Technologies, Inc.

4.70     Hemostasis, LLC

4.71     HyperBranch Medical Technology, Inc.

4.72     Incisive Surgical, Inc.

4.73     Innovasa Corporation

4.74     Integra Lifesciences Corporation

4.75     I-Therapeutix, Inc.

4.76     Johnson & Johnson (Ethicon, Ethicon Endo-Surgery, DePuy Spine)

4.77     Kaketsuken (Chemo-Sero-Therapeutic Research Institute)

4.78     Kensey Nash Corporation

4.79     Kimberly-Clark Health Care

4.80     Kinetic Concepts, Inc.

4.81     King Pharmaceuticals, Inc.

4.82     Kookbo Chemicals Co., Ltd. (KB Chem.)

4.83     Laboratoires Urgo (Urgo Medical)

4.84     Lewis Medical Supplies

4.85     LifeBond Ltd.

4.86     Lifecore Biomedical, Inc.

4.87     Lohmann & Rauscher

4.88     Marine Polymer Technologies

4.89     Medafor, Inc.

4.90     Medi Surgichem Pvt. Ltd.

4.91     MedTrade Products, Ltd.

4.92     Meyer-Haake GmbH Medical Innovations

4.93     Mölnlycke Health Care AB

4.94     Morris Innovative

4.95     Motex Healthcare Corp.

4.96     Myco Medical

4.97     NeatStitch Ltd.

4.98     Neose Technologies Inc. (Novo Nordisk)

4.99     Nycomed

.100     Omrix Biopharmaceuticals Inc.

4.101   Pac-Kit Safety Equipment

4.102   Pfizer Inc.

4.103   Pharming Group NV

4.104   Plasma Technologies, Inc.

4.105   PlasmaSeal

4.106   Pluromed, Inc.

4.107   Polyganics

4.108   Polyheal Ltd.

4.109   ProFibrix BV

4.110   Progressive Surgical, Ltd.

4.111   Protein Polymer Technologies, Inc.

4.112   Radi Medical Systems AB

4.113   Resorba Wundversorgung GmbH & Co. KG

4.114   Scapa Group plc

4.115   Scion Cardio-Vascular, Inc.

4.116   Sea Run Holdings

4.117   Seton

4.118   Smith & Nephew plc

4.119   Starch Medical, Inc.

4.120   Steroplast Ltd.

4.121   Sutura, Inc.

4.122   Synovis Life Technologies

4.123   SyntheMed, Inc.

4.124   Teleflex Medical

4.125   Tenaxis Medical, Inc.

4.126   ThermoGenesis Corporation

4.127   Therus Corporation

4.128   Thrombotargets Corp.

4.129   Tissuemed Ltd.

4.130   TraumaCure, Inc.

4.131   TyRx Pharma Inc.

4.132   Vascular Solutions, Inc.

4.133   Vectura Group plc

4.134   Vivostat A/S

4.135   Z-Medica Corporation

4.136   Zimmer

4.137   ZymoGenetics, Inc.




List of Exhibits

Exhibit ES-1: Recent Acquisitions in the Securement Segment

Exhibit ES-2: Introducers of New Securement Technologies to the U.S. Market

Exhibit ES-3: Definition of Surgical Closure and Securement Products

Exhibit ES-4: Incidence of Two Example Surgical Procedures with High Requirement for Adjunctive Products for Surgical Closure and Securement

Exhibit ES-5: U.S. FDA Approved Uses of Sealants, Glues, and Hemostats

Exhibit ES-6: Synthetic and Biological Sealant Competitors (Non-Fibrin Sealants)

Exhibit ES-7: Selected High-Strength Adhesive Companies and Their Strategies

Exhibit ES-8: Selected Sealant Product Companies and Their Strategies

Exhibit ES-9: Worldwide Growth in the Securement and Closure Market, 2006–2013


Exhibit 1-1: Skin Structure Illustrating Major Organelles and Skin Layers

Exhibit 1-2: Classification of Wounds by Morphology

Exhibit 1-3: Severity Classification of Wounds

Exhibit 1-4: Wound Classification by Etiology

Exhibit 1-5: Prevalence of Different Wound Types, 2008

Exhibit 1-6: Criteria for Adjunctive Use of Hemostats, Sealants, Glues and Adhesion Prevention Products in Surgery

Exhibit 1-7: Surgical Procedures with Potential for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products, Worldwide

Exhibit 1-8: Potential for Cardiovascular Applications, Prevalence of Applicable Surgical Applications

Exhibit 1-9: Potential for Neurological Applications, Prevalence of Applicable Disorders

Exhibit 1-10: Potential for Orthopedic Applications, Frequency of Major Surgical Interventions

Exhibit 1-11: Potential for Urological Applications, Prevalence of Applicable Disorders

Exhibit 1-12: Potential for Dermal Repair, Prevalence of Applicable Disorders

Exhibit 1-13: Applications of Fibrin and Other Sealants

Exhibit 1-14: Surgical Procedures Using Fibrin and Other Sealant Products (2009–2013)

Exhibit 1-15: Surgical Indications for High-Strength Glues (Europe, 2008)


Exhibit 2-1:  Factors That Affect Wound Healing

Exhibit 2-2: Timescales for Development of Closure and Sealant Products

Exhibit 2-3:  Variables Associated With Clinical Evaluation of Closure and Securement and Related Products


Exhibit 3-1: Manufacturers of Surgical Sutures, Staples, Clips, and Other Mechanical Closure Devices

Exhibit 3-2: Worldwide Sutures and Staples Market Forecast, 2009–2013

Exhibit 3-3: Worldwide Suture and Staples Market 2007, Share by Supplier

Exhibit 3-4: Companies Commercializing First Aid Technologies Often Used as Tapes for Closure

Exhibit 3-5: Worldwide Tapes Market Forecast, 2009-2013

Exhibit 3-6: Worldwide Tapes for Closure Market Share, 2007, by Supplier

Exhibit 3-7: Companies Commercializing Technologies in the Hemostat Category

Exhibit 3-8: Worldwide Hemostats Market Forecast, 2009–2013

Exhibit 3-9: Worldwide Hemostats Market Share, 2007, by Supplier

Exhibit 3-10: Companies Commercializing Technologies in the Sealants Category

Exhibit 3-11: Worldwide Sealants Market Forecast, 2009-2013

Exhibit 3-12: Worldwide Sealants Market Share, 2007, by Supplier

Exhibit 3-13: Companies Commercializing Cyanoacrylate-based High-Strength Medical Adhesives

Exhibit 3-14: Worldwide High-Strength Glues Market Forecast, 2009–2013

Exhibit 3-15: Worldwide High-Strength Glues Market Share 2007, by Supplier

Exhibit 3-16: Companies Commercializing Technologies in the Post-Surgical Adhesion Prevention Category

Exhibit 3-17: Worldwide Post-Operative Adhesion Prevention Market Forecast, 2009–2013

Exhibit 3-18: Worldwide Post Operative Adhesion Prevention Market Share, 2007, by Supplier

Exhibit 3-19:  Size and Growth of Wound Closure and Securement Market, World and Selected Countries, 2007

Exhibit 3-20: Wound Closure Market 2007, by Product Segments: The Major American Countries

Exhibit 3-21: Wound Closure Market 2007, by Product Segments: Japan

Exhibit 3-22: Wound Closure Market 2007, by Product Segments: Major European Countries

Exhibit 3-23: Wound Closure Market 2007, by Product Segments: Rest of World

Exhibit 3-24: Growth Forecast for Closure and Securement Market, 2009–2013


Exhibit 4-1: 3M, Selected Financial Data for 2007

Exhibit 4-2: Abbott Laboratories, Selected Financial Data for the First Nine Months of 2008

Exhibit 4-3: Advanced Medical Solutions’ Selected Financial Data for 2006 and 2007

Exhibit 4-4: Angiotech Pharmaceuticals’ Statement of Income for 2nd Quarter, 2008 (Ending June 30)

Exhibit 4-5: Anika Therapeutics’ Financial Results for 2006 and 2007

Exhibit 4-6: ArthroCare Corporation Financial Data

Exhibit 4-7: B. Braun Financial Data

Exhibit 4-8: Baxter International Financial Data

Exhibit 4-9: C.R. Bard, Inc. Financial Data for Nine Months Ending Sept. 30

Exhibit 4-10: Cardiovascular Sciences, Inc. Financial Data

Exhibit 4-11: Covidien, Selected Financial Data, 2007

Exhibit 4-12: CryoLife Financial Results, 2006 and 2007

Exhibit 4-13: Haemacure Corporation, Selected Financial Data

Exhibit 4-14: Integra Lifesciences, Financial Data

Exhibit 4-15: Johnson & Johnson Key Financial Data, 2006 and 2007

Exhibit 4-16: Kimberly-Clark Health Care Financial Data

Exhibit 4-17: King Pharmaceuticals Financial Data

Exhibit 4-18: Overview of Omrix’ Biosurgical Product Pipeline

Exhibit 4-19: Omrix Biopharmaceuticals Financial Data

Exhibit 4-20: Pfizer Financial Data for 2007 and 2006

Exhibit 4-21: Pharming Financial Data

Exhibit 4-22: Teleflex Inc. Financial Data

Exhibit 4-23: Vascular Solutions Financial Results

Exhibit 4-24: ZymoGenetics Financial Data, 3rd Quarter, 2008


Note:  The report described above has been updated by Report #S190, published February 2012.


Patrick Driscoll
tel:  +1.949.891.1753


MedMarket Diligence Reports are produced through primary and secondary research. Data is gathered from published sources on products and technologies on the market and under development.  Clinicians and industry representatives are interviewed for their knowledge and insights on product development, market development, clinical practice and trends associated with the evolving use of technologies. Secondary data is used to corroborate and support assessments and projections.  Reports are written and researched by industry insiders, whose familiarity with the companies, industry dynamics and other marketplace specifics facilitate the research process and ensure high quality and thorough reports.

 Contact: Patrick Driscoll, (949) 891-1753. patrick<at>mediligence<dot>com.

Copyright © 2009 MedMarket Diligence, LLC. All rights reserved.
Revised: 02/16/11


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